Chameleons will not become aggressive when being held as they are generally calm, however, they do not like it.
It is not bad to hold a chameleon but holding them often and excessively may create stress between them and their owner.
Chameleons cannot bond with their owners and do not have emotional receptors in their brains as mammals like dogs do.
Chameleons do not like to cuddle. They can be quite small, due to their small size, it makes it difficult to cuddle with them.
If you believe your chameleon is ill or has any abnormal symptoms, it is important to take them to a veterinarian right away.